VP, Medical Affairs Head of Early Assets

The Vice President, Head of Early Assets, serves as the strategic and scientific leader for Alnylam's earlystage medical programs across CNS, cardiovascular, and hematology indications. As a key member of the Medical Affairs Leadership Team (MALT), this leader holds primary accountability for defining and executing the global medical strategy for multiple earlystage assets and shaping Alnylam's future portfolio direction.

The VP will influence enterpriselevel investment and development decisions, lead and develop a highperforming team of medical directors, and partner closely with Program Leadership, Commercial, Clinical Development, Value & Evidence Strategy (VeST), and Patient Advocacy to ensure integrated, datadriven, crossfunctional plans. This role is central to establishing early medical strategy, advancing evidence generation, and preparing markets for future launch success.

Summary of Key Responsibilities

Strategic Leadership & Enterprise Impact

• Lead the development and execution of the global medical strategy for multiple early-stage programs, ensuring alignment with overall Medical Affairs and enterprise priorities.
• Provide strategic insight to shape early asset development, informing long-term planning, investment decisions, and portfolio growth opportunities.
• Serve as the primary medical affairs leader for early programs, influencing enterprise-wide decision-making through active engagement with Program and Product Commercialization teams.

Cross-Functional Collaboration & Evidence Generation

• Partner with Program Teams to design and guide integrated evidence frameworks and long-term evidence generation plans, ensuring medical perspectives inform pivotal study design and lifecycle strategy.
• Collaborate with Clinical Development and VeST to ensure early clinical and real-world evidence needs are incorporated into study planning and execution.
• Drive alignment with the Scientific Communications team to ensure timely, accurate, and strategic dissemination of scientific data.

Market, Patient, and External Stakeholder Strategy

• Partner with Commercial to assess unmet need, epidemiology, market opportunity, and competitive landscape, shaping early market development activities.
• Lead KOL and early external engagement strategy to understand evolving clinical practice, guideline gaps, and real-world barriers.
• Partner with Patient Advocacy to ensure the voice of the patient and community insights inform program design, recruitment strategies, and broader development planning.

Medical Affairs Excellence & Team Leadership

• Build, lead, and develop a highperforming team of medical directors and cross-regional partners, operating as a true playercoach-providing strategic direction while remaining handson in critical workstreams to model excellence, accelerate execution, and develop talent.
• Ensure the development of high-quality, globally relevant medical plans that support disease education, market development, and future launch readiness.
• Partner with Medical Training to drive scientific readiness and capability building across the medical organization.

Qualifications

• MD, PhD in life sciences, or PharmD
• 15+ years of progressive experience in Medical Affairs within pharmaceutical or biotechnology environments, with strong exposure to early clinical development.
• 5+ years of leadership experience, including managing directors and senior scientific staff.
• Demonstrated experience leading across multiple therapeutic areas; cardiovascular expertise is a plus.
• Strong understanding of evidence generation principles, regulatory considerations, and healthcare ecosystem dynamics.
• Reputation as a respected, visionary leader with the ability to influence across a matrixed organization.
• Demonstrated ability to build high performing teams, drive organizational change, and execute against complex, cross functional goals.
• Exceptional communication, leadership presence, and interpersonal skills.

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U.S. Pay Range

$361,400.00 - $488,700.00

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

AboutAlnylam

We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.