New

Senior Research Scientist

California Institute of Technology
vision insurance, parental leave, paid time off, sick time, tuition reimbursement
United States, California, Pasadena
Feb 20, 2026
Caltech is a world-renowned science and engineering institute that marshals some of the world's brightest minds and most innovative tools to address fundamental scientific questions. We thrive on finding and cultivating talented people who are passionate about what they do. Join us and be a part of the diverse Caltech community. Job Summary The Mayo Laboratory at the California Institute of Technology (Caltech) seeks a highly motivated Senior Research Scientist with a PhD and postdoctoral training in immunology to advance the lab's research programs focused on autoimmune disease, antigen-specific immune tolerance, and translational immunology. Must have substantial scientific independence, project ownership, and opportunities to shape the strategic direction of the lab's research that follows from the recent Olson et al. PNAS publication (doi: 10.1073/pnas.2501046122). Essential Job Duties Design, execute, and interpret complex in vitro and in vivo immunology experiments. Drive data generation for high-impact publications and grant applications. Analyze and present data at lab meetings, conferences, and in manuscripts. Coordinate collaborations between labs, core facilities, academic institutions, and companies. Mentor graduate students, postdoctoral fellows, and/or research staff as appropriate. Contribute to grant preparation and scientific reporting. Basic Qualifications PhD in Immunology or a closely related biomedical discipline. Must have a minimum of 8 years of relevant experience. Postdoctoral research experience with a strong publication record. Deep expertise in cellular and molecular immunology. Demonstrated expertise in techniques such as flow cytometry, immune cell culture and functional assays, ELISA, Western, cytokine profiling, antigen-specific readouts, murine or other in vivo models of immune function or autoimmunity. Excellent analytical, organizational, and written and verbal communication skills. Preferred Qualifications Experience with autoimmune disease, immunetolerance, or chronic inflammation. Familiarity with translational or preclinical research concepts. Experience with advanced platforms such as single-cell RNA-seq, TCR repertoire analysis, or immunogenomics. Interest in therapeutic modalities (e.g., biologics, nanoparticles, gene-based approaches). Required Documents Resume Hiring Range $78,200 - $147,500 Per Year The salary of the finalist(s) selected for this role will be set based on a variety of factors, including but not limited to, internal equity, experience, education, specialty and training. As one of the largest employers in Pasadena, CA, Caltech is committed to providing comprehensive benefits to eligible employees and their eligible dependents. Our benefits package includes competitive compensation, health, dental, and vision insurance, retirement savings plans, generous paid time off (vacation, holidays, sick time, parental leave, bereavement, etc.), tuition reimbursement, and more. Non-benefit eligible employees will have access to some benefits such as onsite counseling and sick time. Learn more about our benefits and staff perks. EEO Statement We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to age, race, color, religion, sex, sexual orientation, gender identity, or national origin, disability status, protected veteran status, or any other characteristic protected by law. Caltech is a VEVRAA Federal Contractor. To read more Equal Employment Opportunity (EEO) go to eeoc_self_print_poster.pdf. Disability Accommodations Caltech complies with the Fair Employment and Housing Act (FEHA) and the Americans with Disabilities Act (ADA). We consider reasonable accommodation measures that may be necessary for eligible applicants and employees to perform the essential functions of a position. If you would like to request an accommodation to complete this application, interview, or otherwise participate in the employee selection process, please contact Caltech Recruiting at employment@caltech.edu. Additionally, if you do not meet the basic qualifications of a role but believe you can perform the essential functions of the job with reasonable accommodation, please reach out to Caltech Recruiting at employment@caltech.edu.