Principal Scientist, Genomic Technologies

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Principal Scientist, Genomic Technologies

We are seeking innovative scientists to join our team as a Principal Scientist. Within GSK R&D Translational Sciences (TSci), the Genomic Technologies team integrates deep and broad expertise in computational and statistical methods and techniques, to enable best-in-class analytical insight and interpretation of genetics and genomics data, impacting GSK R&D portfolio and pipeline decisions.

We value collaborative working, and scientific evaluation of different approaches to improving our capabilities in areas of focus for Genomic Technologies, including:

• Discovery of new causal gene-phenotype links, by advancing methodology for analysis of large-scale biobank individual human genetic data, and of GWAS/xQTL summary statistics.
• Identification of causal mechanisms, candidate biomarkers, disease subtypes and patient subgroups, by analysing and integrating genetic, multi-'omic, and phenotypic data from human populations and from genome-scale gene editing perturbation experiments.
• Predictive modelling of presence, direction and magnitude of causal gene-phenotype links, using genetic and 'omic data, mechanistic annotation, inferred causal networks, and genome-scale perturbation data.

In this role you will:

This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include some of the following:

• Generate large-scale analysis outputs, and/or implement state-of-the-art tools for dynamically analysing, interpreting, and visualizing genetic and genomic data.
• Evaluate, improve, test, and develop production implementations of best-in-class methods for analysis of genetics and genomics data, in collaboration with scientists in Translational Sciences, Biostatistics, Data Automation and Predictive Sciences, or/and AI/ML teams.
• Collaborate with partners across TSci, in experimental Target Discovery, and in GSK disease area Research Units, to influence portfolio and pipeline decisions.
• Stay informed about recent research in the field and considering its potential for application within GSK.
• Contribute to a culture of innovation, quality, and willingness to learn and improve.

Why you?

Basic Qualifications & Skills:

We are looking for professionals with these required skills to achieve our goals:

• Advanced degree (PhD or equivalent) in a relevant scientific discipline.
• Experience with genetic, genomic, epigenomic, or experimental/functional genomic data, and with state-of-the-art methods for data analysis and interpretation.
• Excellent programming skills in R or/and python, and application of techniques in reproducible research, literate programming, FAIR data principles, or software development.
• Experience of evaluating, improving, testing, and/or developing methods for analysis and interpretation of large-scale genetics or genomics data.
• Strong communication and team-working skills.

Preferred Qualifications & Skills:

Please note the following skills are not necessary, just preferred, if you do not have them, please still apply:

• Experience with machine learning and/or advanced statistical methods.
• Experience working in multidisciplinary teams on complex and impactful projects.
• Experience with integrating information across multiple genetic, genomic, epigenomic, or experimental/functional genomic data types.
• Experience with analysis of very large datasets using distributed or cloud computing technologies (e.g. SQL, PySpark, BigQuery, Docker, Nextflow).

Closing Date for Applications - 13th February 2026

Please take a copy of the Job Description, as this will not be available post closure of the advert.
When applying for this role, please use the 'cover letter' of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people's lives.GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients' needs and have the highest probability of success. We're uniting science, technology, and talent to get ahead of disease together.

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Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive.

We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases - to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we're committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

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