Lab Research Supervisor - 137924

The Department of Medicine (DOM) is the largest department within the UCSD School of Medicine and is responsible for fulfilling the teaching, research, and clinical missions of the University of California, San Diego School of Medicine. The department employs approximately 500 salaried faculty, 168 academic appointees, 331 residents, fellow and postdocs and 479 staff personnel.

The Lab Manager supports a vibrant research team comprising more than ten research staff, postdoctoral researchers, project scientists, graduate students, and undergraduate students in the Jamieson Lab at UC San Diego. This position manages all aspects of the lab, overseeing and directing daily operations and the work of laboratory personnel. Responsible for assisting in hiring, training, and guidance of laboratory personnel. The Lab Manager will lead and supervise the experiments for various projects focused on the laboratory research objectives involving in vivo animal studies in novel immune-compromised mouse models of leukemia to meet existing grant objectives/milestones and other cooperative funding objectives that support translational cancer research, including performing surgical orthotopic implantation of parental and shRNA-transferred leukemia primary patient samples, intra-hepatic, tail injections, or intra-femoral, and in vivo quantitative imaging.

The Lab Manager will provide instruction on lab protocols and procedures to students and staff. Contribute novel ideas of major methodological significance to the research projects, designing key experiments, and developing new techniques. Author or co-author of scientific journal manuscripts and book chapters. Report directly to funding agencies and journal editors. Prepare and implement research study budgets based on analysis of data. Responsible for managing lab operations, including space management, shipment of study samples to off-site labs for analysis, and maintaining and tracking experimental supply budgets for all projects.

The Lab Manager will also organize and lead experiments for research missions in low-earth orbit and coordinate with NASA and other space implementation partners regarding in-flight research experiments, imaging, and downmass.

Under minimal supervision, oversees the activities and staff of a laboratory including the supervision of entry / intermediate level research and / or instructional associates and laboratory support staff. Typically works in small to medium or single facility laboratory. Supervises the development and execution of major or multi-disciplinary research projects or instructional and experiment design.

• Seven years of related experience, education/training, OR an Bachelor's degree in related area plus three years of related experience/training.

• Advanced knowledge of research discipline or instructional design to collaborate effectively with faculty and function as a resource to research and instructional associates. Advanced theoretical knowledge of leukemia stem cells, biochemistry, cellular and molecular biology, including experience in establishing, maintaining, transfecting, and selecting clones from leukemic cell primary patients samples with expertise in sterile technique. Demonstrated experience with processing and ficolling patient peripheral blood and bone marrow in order to perform cryogenic database management. Scientific knowledge of DNA plasmids and primers.

• Focus of knowledge and skills dependent on area of specialty (laboratory research or instructional / experimental design). Advanced and highly specific knowledge and expertise associated with conducting and reporting on scientific research experiments and findings. Theoretical knowledge in Molecular Biology or Biological Sciences generally acquired through a Bachelor's degree or an equivalent combination of education and experience. Demonstrated experience as a scientific leader. Experience with independently conceptualizing a project, designing protocols, planning for milestones, and preparing results for publication. Experiences project management and leadership skills with designing experiments for low-earth orbit.

• Advanced knowledge of a limited variety of specialized laboratory equipment. Proven skill in the operation and maintenance of various lab equipment such as confocal and quantitative fluorescent microscopes, centrifuges, nanodrop, IVIS imaging machine, and flow cytometer. Demonstrated ability to train others to use lab equipment.

• Leadership skills associated with planning work assignments, establishing priorities and scheduling instructional space. Ability to manage and oversee the daily operations of a lab. Experience to plan, coordinate, provide work direction to staff and other lab personnel, and organize professional training for lab. Ability and willingness to share information and serve as a mentor, and assist in hiring personnel. Experience with HR processes.

• Solid interpersonal skills to develop and maintain effective working relationships with students, faculty and staff.

• Knowledge of data acquisition and analysis techniques.

• Solid interpersonal communication skills to effectively supervise staff. Excellent interpersonal skills including tact, diplomacy and flexibility with the ability to work in a team framework in conjunction with principles of community with staff, faculty, students, and external contacts.

• Ability to conduct and report on scientific experiments and findings. Skill in experimental design and adaptation of methods to achieve results. Ability to integrate data from multiple sources to synthesize conclusions. Ability to read and abstract scientific articles and apply to the design of experiments. Experience in the official review of manuscripts for publication in peer-review journals, including all interactions with Reviewers and Editors, and in the evaluation of grant proposals for potential funding.

• Knowledge of necessary lab safety procedures and requirements, as well as chemical disposal guidelines. Knowledge of basic lab safety requirements/procedures, EH&S regulations and methods to properly handle, clean-up, and dispose of biohazard materials, and regulations for safe record keeping. Strong organizational skills, including experience in laboratory record keeping, budget analysis and managing logistics. Demonstrated knowledge of lab safety rules.

• Demonstrated experience in caring for and handling small lab animals (mice, rats, guinea pigs, and rabbits) and in administering medications and anesthesia to perform phlebotomy and minor surgical procedures on animals. Experience in euthanizing small laboratory animals. Familiarity with the writing of Animal Subjects protocols and with the surgical procedures. Willingness and ability to work with rodents and/or other lab animals and/or infected samples.

• Experience with Institutional Research Board (IRB) protocol(s) submissions, amendments, and correspondence. Write and implement clinical protocols related to sample collection and processing.

• Demonstrated experience in DNA and RNA extraction and use of extracted products in various PCR methods.

• Must be willing to work evenings and weekends when necessary.

• Must be willing to work with small animals.

• Must be willing to work with biohazardous and hazardous materials.

• Employment is subject to a criminal background check.

If employed by the University of California, you will be required to comply with our Policy on Vaccination Programs, which may be amended or revised from time to time. Federal, state, or local public health directives may impose additional requirements.

If applicable, life-support certifications (BLS, NRP, ACLS, etc.) must include hands-on practice and in-person skills assessment; online-only certification is not acceptable.

UC San Diego Health Sciences is comprised of our School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences, The Herbert Wertheim School of Public Health and Human Longevity Science, and our Student Health and Well-Being Department. We have long been at the forefront of translational - or "bench-to-bedside" - research, transforming patient care through discovery and innovation leading to new drugs and technologies. Translational research is carried out every day in the hundreds of clinical trials of promising new therapies offered through UC San Diego Health, and in the drive of our researchers and clinician-scientists who are committed to having a significant impact on patient care. We invite you to join our team!

Applications/Resumes are accepted for current job openings only. For full consideration on any job, applications must be received prior to the initial closing date. If a job has an extended deadline, applications/resumes will be considered during the extension period; however, a job may be filled before the extended date is reached.

To foster the best possible working and learning environment, UC San Diego strives to cultivate a rich and diverse environment, inclusive and supportive of all students, faculty, staff and visitors. For more information, please visit UC San Diego Principles of Community.

The University of California is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected status under state or federal law.

For the University of California's Anti-Discrimination Policy, please visit: https://policy.ucop.edu/doc/1001004/Anti-Discrimination

UC San Diego is a smoke and tobacco free environment. Please visit smokefree.ucsd.edu for more information.

UC San Diego Health maintains a marijuana and drug free environment. Employees may be subject to drug screening.

Misconduct Disclosure Requirement: As a condition of employment, the final candidate who accepts an offer of employment will be required to disclose if they have been subject to any final administrative or judicial decisions within the last seven years determining that they committed any misconduct; or have filed an appeal of a finding of substantiated misconduct with a previous employer.

a. "Misconduct" means any violation of the policies governing employee conduct at the applicant's previous place of employment, including, but not limited to, violations of policies prohibiting sexual harassment, sexual assault, or other forms of harassment, or discrimination, as defined by the employer. For reference, below are UC's policies addressing some forms of misconduct:

• UC Sexual Violence and Sexual Harassment Policy
• UC Anti-Discrimination Policy
• Abusive Conduct in the Workplace