Cell Culture Development Senior Research Associate

Pharma Technical Cell and Gene Therapies (PTC) focuses on developing robust manufacturing processes and quality control systems to efficiently transform scientific ideas into products. PTC reliably delivers quality products to patients enrolled in clinical studies around the world. PTC excels by creating an engaging and inclusive environment where everyone can bring their skills and talents to developing innovative medicines.

As a Cell Culture Development Senior Research Associate, you will be responsible for producing viral vector drug substance (DS) using both upstream and downstream process operations. Utilizing systems including ambr250ht and bench-scale bioreactors, as well as small-scale chromatography, centrifugation, and filtration systems, you will drive the delivery of preclinical material to Pharma Technical Cell and Gene Therapies (PTCG) Research teams.

The Opportunity:

In this role, you will provide support to different functional groups within PTCG and Research and Early Development (pRED and gRED) and actively participate in cross-functional teams consisting of members from all areas of process development. You will author and review protocols, technical reports, and standard operating procedures. Additionally, you will:

• Independently develop and execute production batches including seed train, bioreactor production, harvest, chromatography, dialysis, TFF, and filtration operations.

• Coordinate product quality testing through Analytical and Quality Control (AQC) organization.

• Evaluate, summarize, present, and document in-process and analytical data resulting from production batches.

• Author and/or review technical development documents.

• Maintain vector and critical raw material inventories and material transfer to cross-functional colleagues.

• Hands-on, technical execution in the laboratory while providing mentorship to junior colleagues.

• Maintain timely and accurate lab records consistent with good documentation practices.

• Serve as a technical expert or representative and provide process knowledge and expertise to cross-functional teams.

Who You Are

• You possess a B.S. in Biochemistry, Biotechnology, Chemical Engineering or related field with 8+ years of industry experience.

• You have hands-on, practical expertise in seed train, bioreactor production, harvest, chromatography, dialysis, TFF, and filtration operations at lab (bench) scale.

• You are self-motivated, have excellent organization, oral and written communication skills, and have demonstrated skills to work both independently and as a collaborative team member.

• You have demonstrated experience presenting data and insights for various audiences.

• You thrive in a dynamic, fast-paced environment and excel at managing various responsibilities while consistently meeting deadlines.

Preferred Experience:

• Ph.D. in Biochemistry, Biotechnology, Chemical Engineering or related field with 2+ years of industry/post-doctoral experience or M.S. in Biochemistry, Biotechnology, Chemical Engineering or related field with 4+ years of industry experience

• Previous experience working with AAV gene therapy process development

• Hands-on expertise utilizing Sartorius ambr250ht and Eppendorf BioFlo bioreactor systems for pharmaceutical production, including data analysis.

• Hands-on expertise utilizing AKTA Avant and/or Protein BioSolutions Protein Maker chromatography systems, including data analysis.

• Working knowledge of documentation systems and electronic lab notebooks, along with best practices.

• Working knowledge of statistical methods and software (JMP), data analytics or multivariate analysis.

Relocation benefits are not approved for this posting.

The expected salary range for this position based on the primary location of Philadelphia, PA is $97,090 (min) - $138,700 (mid) - $180,310 (max). Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed in this link.

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Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

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