Research Post Doctoral Fellow - Samelson-Jones Lab

A Brief Overview

Assume responsibility for an on-going, innovative research project as a Postdoctoral Fellow at CHOP. Our postdoc experience will broaden your skillset, scientific background, and research capabilities.

CHOP's Commitment to Diversity, Equity, and Inclusion
CHOP is committed to building an inclusive culture where employees feel a sense of belonging, connection, and community within their workplace. We are a team dedicated to fostering an environment that allows for all to be their authentic selves. We are focused on attracting, cultivating, and retaining diverse talent who can help us deliver on our mission to be a world leader in the advancement of healthcare for children.

We strongly encourage all candidates of diverse backgrounds and lived experiences to apply.

About the Laboratory

The postdoctoral fellow (postdoc) will have a terminal degree PhD, MD, or MD-PhD and will, under the direction/guidance of a mentor (Dr. Samelson-Jones, MD, PhD), assume responsibility for a specific, ongoing research project focused on understanding the interaction between activated factor VIII and IX and how it can be bypassed as a treatment for hemophilia B. The postdoc experience will serve to extend, refine, and enhance skills necessary for professional and career development, and will enable the individual to broaden his/her scientific background by acquiring new research capabilities. It is expected that this individual will conduct independent scholarly research and will contribute directly to the overall research goals of the project and the research group. Postdocs will be expected to participate in/lead project planning, recording and interpretation/evaluation of data, and communication of results. Postdocs will also be expected to acquire technical, lab management, and manuscript/grant writing skills; and participate in seminars, lectures, poster sessions, and presentations at national meetings. Postdoctoral fellows also may be required to supervise junior lab members, develop new methods and protocols for research, and assist with the development of other research projects in the lab.

SKILLS AND ABILITIES:

Strong research skills

Effective problem solving/critical thinking skills

Ability to work independently

Ability to exercise discretion and judgment

Value for research integrity and collaborative research

High level of motivation

Good communication skills

Strong interpersonal skills

SPECIFIC LAB INFORMATION:

The Not Bleeding Frontier Program (https://www.chop.edu/get-involved/frontier-programs) will provide an ideal training environment for scientists interested in translational research. The Samelson-Jones laboratory is part of the Division of Hematology at CHOP and the Raymond G. Perelman Center for Cellular and Molecular Therapeutics (https://ccmt.research.chop.edu) that includes a team of investigators committed to developing protein, cell, and gene therapy approaches to treat genetic disease, including hemophilia.

The Children's Hospital of Philadelphia and University of Pennsylvania offer a rich scientific environment for training in hemostasis and thrombosis. With over 30 laboratories dedicated to this space, a center dedicated to blood research, multiple NIH training grants, collaborative laboratories, cross campus meeting, and focus on mentorship and training, it is an ideal environment to start or expand your career in the blood sciences.

Dr. Samelson-Jones' laboratory studies the molecular basis of coagulation and how disturbances in their function lead to disorders of bleeding and thrombosis. We are interested in translating basic molecular and biochemical insights to improve therapeutics for disorders of hemostasis, namely hemophilia.

A variety of enzymatic, biochemical, and molecular biology techniques are used in the laboratory in order to carry out our specific goals. For example, the following techniques are routinely performed in the laboratory: modern molecular methods (site-directed mutagenesis, cloning, etc.), tissue culture, protein purification, HPLC, FPLC, SDS-PAGE, ELISA, enzymatic kinetic assays, fluorescence spectroscopy, fluorescence anisotropy measurements, and mouse modeling of hemostasis.

More info can be found at:

https://www.research.chop.edu/people/benjamin-j-samelson-jones

https://www.research.chop.edu/samelson-jones-laboratory

https://www.med.upenn.edu/apps/faculty/index.php/g275/p8582239

Responsibilities

• Participate in project planning, recording, and evaluation of data.

• Conduct independent scholarly research, developing new methods and protocols under the guidance of a mentor (principal investigator).

• Acquire technical, lab management, and grant writing skills.

• Participate in seminars, lectures, poster sessions, national presentations, and professional workshops.

• Supervise junior lab members.

• Assist with other research projects as needed.

Education

• Required: Doctorate