Manufacturing Technician

Job Title: Manufacturing Associate

Location: Berkeley, CA

Duration: 6+ Months (Possibility of Extension & Conversion depending on Performance)

Pay Rate: $36-48/hr.

Shift start times are as follows : 6am - 2:30pm, 6pm-2:30 am, 6:30am-3pm, 2:30pm-11pm, 10:30pm-7am

Cell Culture bioreactor system assembly and use, including control of gas supply to bioreactor, Micro-sparger assembly, Anti-Foam Emulsion system. Ability to troubleshoot and control processes.
o Continuous Cells Separation equipment preparation and process/controls.
o Membrane Absorption Chromatography process (e.g. Membrane Absorption process, Buffer and NaOH supply, cTCF supply, Capsule preparation, Inline dilution and Temperature controls).
o Basic knowledge of protein chemistry and purification systems such as anion, cation, and immunoaffinity chromatography.
o Membrane Absorber technology, viral removal techniques and tangential flow filtration technology. Large scale chromatography, TFF technology.
o Familiarity with cGMP's and applicable agency regulations

Prepares process equipment (including but not limited to Bioreactors & ancillary equipment, Stainless Steel tanks, Pressure Transmitters, Flow Meters, Aggregate traps, Harvest discards, Transfer lines (buffers, cTCF), Hoses and small parts.

* Cleans and Sterilizes equipment using appropriate CIP (Clean-In-Place), SIP (Steam-In*Place) procedures.
* Performs daily or routine process operations in the cell culture and purification of biotech and biological products (Kovaltry, Kogenate, and Jivi). Operates equipment for these processes including:
o Inoculates and monitors bioreactors.
o Processes cTCF material to Continuous Cell Separation (CCS).
o Operates Chromatography, MAEF, MAVF and TFF skids.
o Processes MAEF material using closed thaw process, step elution chromatography, Membrane Absorber and filter clearance technology, and gradient controlled SP column
separation techniques.
o Operates 50L, 200L and 1000L collection bag technology to ensure robust collection, mixing and dilution of products.
o Performs PEGylation of JIVI in process material using TFF technology.
o Operates automated bagging systems.
o Blast Freezes product for storage.
o Dispenses chemicals and formulate solutions.
o Prepares acids and bases as necessary.
* Performs aseptic operations.
* Takes, analyzes and submits samples as required throughout the process.
* Monitors and controls operation with computer control systems.
* Completes all routine check sheets.
* Cleans equipment and maintains clean and orderly production facilities.
* Performs in-depth troubleshooting and root cause analysis of Kovaltry, Kogenate, and Jivi equipment and process failures.
* Contributes to continuous improvement opportunities.
* Performs all operations in compliance with cGMP.
* Performs other related duties as assigned.
Qualifications & Competencies:
Required Qualifications:
* Requires completion of two-years' college science courses in (e.g. biology, chemistry,
biochemistry, or microbiology) or a certificate from an accredited bio-technology academy.
* Relevant bio-tech industry experience in some or all of the following is preferred, and may
be considered in lieu of some or all of the educational requirements above

Dexian is a leading provider of staffing, IT, and workforce solutions with over 12,000 employees and 70 locations worldwide. As one of the largest IT staffing companies and the 2nd largest minority-owned staffing company in the U.S., Dexian was formed in 2023 through the merger of DISYS and Signature Consultants. Combining the best elements of its core companies, Dexian's platform connects talent, technology, and organizations to produce game-changing results that help everyone achieve their ambitions and goals.

Dexian's brands include Dexian DISYS, Dexian Signature Consultants, Dexian Government Solutions, Dexian Talent Development and Dexian IT Solutions. Visit https://dexian.com/ to learn more.

Dexian is an Equal Opportunity Employer that recruits and hires qualified candidates without regard to race, religion, sex, sexual orientation, gender identity, age, national origin, ancestry, citizenship, disability, or veteran status.