New 
Postdoctoral Research Fellow in the Department of Pathology at Brigham and Women's Hospital/Harvard Medical School
 Mass General Brigham (Enterprise Services) | |
 United States, Massachusetts, Boston | |
| 75 Francis Street (Show on map) | |
 Jun 04, 2025 | |
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Postdoctoral position available to study mechanisms of response to immune checkpoint inhibitors in kidney cancer.
Immunotherapy with immune checkpoint inhibitors (e.g. anti-PD-1/PD-L1 agents) has demonstrated clinical efficacy in metastatic renal cell carcinoma (mRCC). Unfortunately, only a subset of mRCC patients responds to these agents. To guide further clinical development of immune checkpoint inhibitors in kidney cancer, we aim to 1) develop and validate tissue-based predictors of drug response using both genomics approaches and in situ analyses; 2) understand the mechanism of action of PD-1/PD-L1 blockade to facilitate the development of highly active combination regimens. Requirements: We are seeking a highly motivated applicant with an M.D. or M.D./Ph.D. with strong laboratory experience in pathology and molecular biology. Candidates with formal training in Anatomic Pathology (at least 1 year in residency program) are highly preferred. Background in bioinformatics/computational biology is desirable. Excellent written and oral communication skills are required. The candidate must be willing to commit to the position for at least two years. If interested, please send a cover letter, CV and three references to: Sabina Signoretti M.D. Mass General Brigham Incorporated is an Equal Opportunity Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. | |