ViiV Healthcare Senior Director, Discovery Toxicology.

ViiV Healthcare is a pharmaceutical company specializing in the development of therapies for HIV infection that was created as a joint venture by Pfizer and GlaxoSmithKline in November 2009 with both companies transferring their HIV assets to the new company. At ViiV Healthcare our scientists are 100% dedicated to finding new ways to limit the impact of HIV on the 35 million people living with the virus.

The goal of the Discovery research team is to identify drug targets, design assays to identify molecules which interact with these targets and develop these molecules through iterative processes to identify novel drug candidates.

As a Senior Director of Discovery Toxicology, you will be responsible for developing the non-clinical safety strategy for ViiV Healthcare's Discovery portfolio. In this role, you will manage a talented team dedicated to addressing non-clinical toxicity issues from an investigative and/or mechanistic perspective. You will work in a highly matrixed global environment and collaborate extensively to evolve preclinical safety strategies based on input from market research, competitive intelligence, and learnings from internal programs. You will also work to integrate Discovery non-clinical plans with CMC, regulatory, and clinical plans to optimize speed of drug development. Additionally, you will have the opportunity to oversee the toxicology strategy for compounds in development as a project team member.

This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include some of the following:

• Responsible for all aspects of non-clinical safety/toxicology assessment of drug candidates up to and including candidate selection.

• Provide strategic planning and oversight to Discovery lead op teams to ensure robust plans in place to support timely nomination of high-quality molecules for candidate selection.

• Streamline non-clinical safety/toxicology package and overall candidate selection processes by effectively using resources in house (local and GSK) and at CROs.

• Identify areas for improvement and help increase efficiency of operation. Tailor these processes to meet the project needs. Cross train scientists to manage some of these processes.

• Ensure smooth transition from Candidate Selection to Early Development with proactive planning and communication.

• Work with ViiV Head of Discovery to determine areas of focus for investigative toxicology efforts.

• Work with Discovery heads of chemistry, virology, pharmaceutics and DMPK to drive Discovery strategy and optimization of processes.

• Improve overall candidate optimization strategy for long-acting injectable (LAI) formulations, biologics and alternate platforms, working across disciplines.

• Explore strategies for safety assessment of 1) novel LAIs, especially those with limited oral lead-in capability, and 2) biologics/small molecules with host target and potential on target toxicities.

• Explore novel ways to reduce the LAI time for CS / development and number of animal studies by an integrated candidate characterization strategy.

• Collaborate internally with GSK preclinical sciences organization and externally with academic institutions to leverage and enhance scientific capabilities.

• Ensure maintenance of safe and fully EH&S compliant operational practices in the workplace as applicable.

• Responsible for delivery of non-clinical safety/toxicology documents

• Serve as Toxicology team member on Discovery and Early Development projects, as needed.

• Manage and mentor team of Discovery Toxicologists.

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:

• Masters OR PhD with 15+ years of experience in toxicology, including 5+ years FLL or Leadership experience across a matrix

Preferred Qualifications:

If you have the following characteristics, it would be a plus:

• Experience in non-clinical discovery and development of long-acting small molecules, biologics, and/or gene therapy

• DABT (Diplomat of American Board of Toxicology)

• HIV Drug Development Experience

#LI-ViiV

#LI-GSK

Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program ViiV offers US employees. All ViiV employees receive the same benefits options and plans as GSK employee.

Why Us?

At ViiV Healthcare, we will not rest until we leave no person living with HIV behind. Until the 39 million people living with HIV is down to zero, we will continue searching for new ways to limit the impact of HIV.

We are the only pharmaceutical company solely focused on combating, preventing, and ultimately eradicating HIV and AIDS. At ViiV Healthcare, we do things differently. Born out of a partnership between GSK and Pfizer in 2009, with Shionogi joining in 2012, we are determined to help end the HIV epidemic. We are guided by our mission to leave no person living with HIV behind and it is this mission that unites our employees located across the globe. We combine expertise in research, manufacturing, policy and more to push the boundaries of what people think is possible in HIV treatment and care. As a result of our connection with GSK, we are able to draw on their proud history and resources. This means that you would receive all the employee benefits offered by GSK.

Living our mission of leaving no person living with HIV behind means keeping inclusion and diversity at the heart of everything we do - from our breakthrough innovation, to our diverse portfolio of medicines as well as the work we do to partner with HIV communities. Having atruly inclusive culture where we're all able to be ourselves and feel like we belong will make us an even stronger team, better able to perform as a business and deliver on our mission to leave no person living with HIV behind.

If you require an accommodation or other assistance to apply for a job at ViiV, please contact the ViiV Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).

ViiV is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

Important notice to Employment businesses/ Agencies

ViiV does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact ViiV's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to ViiV. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and ViiV. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of ViiV. ViiV shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.

Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, ViiV may be required to capture and report expenses ViiV incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure ViiV's compliance to all federal and state US Transparency requirements. For more information, please visit the Centers for Medicare and Medicaid Services (CMS) website at https://openpaymentsdata.cms.gov/